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Phenotypes Associated with This Genotype
Genotype
MGI:5427889
Allelic
Composition
Pik3c3tm1.1Flv/Pik3c3tm1.1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3tm1.1Flv mutation (0 available); any Pik3c3 mutation (45 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mainly due to loss of cells with naive (CD44lo) phenotype

cellular
• T cells treated with BafA1 exhibit reduced autophagy activity compared with control cells

hematopoietic system
• mainly due to loss of cells with naive (CD44lo) phenotype

homeostasis/metabolism
• T cells treated with BafA1 exhibit reduced autophagy activity compared with control cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory