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Phenotypes Associated with This Genotype
Genotype
MGI:5427842
Allelic
Composition		 P2rx6tm1Dgen/P2rx6tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx6tm1Dgen mutation (2 available); any P2rx6 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:82809 )
• homozygous mice required a significantly increased dose of metrazol to reach various seizure stages, when compared with age- and gender-matched wild-type control mice
increased thermal nociceptive threshold ( J:82809 )
• homozygous mutant mice exhibited a significant increase in thermal response latency during hot plate testing

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:82809 )
• homozygous mice required a significantly increased dose of metrazol to reach various seizure stages, when compared with age- and gender-matched wild-type control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory