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Phenotypes Associated with This Genotype
Genotype
MGI:5427100
Allelic
Composition		 Tmc1tm1.1Ajg/Tmc1tm1.1Ajg
Genetic
Background		 B6.129-Tmc1tm1.1Ajg
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Mouse lines carrying:
Tmc1tm1.1Ajg mutation (1 available); any Tmc1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal hair cell mechanoelectric transduction ( J:184419 )
• significant reduction in current amplitude in outer hair cells from the apical cochlea at P5-P7 but not in cells from the basal turns at P2-P4
increased or absent threshold for auditory brainstem response ( J:184419 )
• increased ABR threshold at all frequencies tested
deafness ( J:184419 )
• profound

behavior/neurological
behavior/neurological phenotype ( J:184419 )
N
• normal motor behavior

nervous system
abnormal hair cell mechanoelectric transduction ( J:184419 )
• significant reduction in current amplitude in outer hair cells from the apical cochlea at P5-P7 but not in cells from the basal turns at P2-P4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory