Analysis Tools
homeostasis/metabolism
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• by 4 weeks in mice fed a western diet
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• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit impaired reverse cholesterol transport compared with control mice
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• by 4 weeks in mice fed a western diet
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• in mice fed a western diet at the conclusion of the experiment
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• mice fed a western diet and treated with T0901317 (an Lxr/Nr1h3 agonist) fail to exhibit a change in plasma lipid levels or an increase in fecal excretion of macrophage-derived sterols but an increase in hepatic sterols compared with control mice
• however, treatment with T0901317 reduces atherosclerosis as in controls
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liver/biliary system
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• in mice fed a western diet at the conclusion of the experiment
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cardiovascular system
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• mice fed a western diet exhibit increase in lesion size as detected by macrophage staining compared with control mice
• however, collagen staining or lesions is normal and treatment with T0901317 reduces atherosclerosis as in controls
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