Phenotypes Associated with This Genotype

Genotype
MGI:5427002

• Allelic Composition: Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:184536 )

• mice treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit an attenuated increase in plasma triglycerides, hepatic triglycerides, biliary cholesterol, biliary cholesterol secretion and fecal neutral sterols but an attenuated decrease in CAMCA bile acid composition and cholesterol absorption compared with control mice

increased liver cholesterol level ( J:184536 )

• in mice fed a 2% cholesterol diet

decreased physiological sensitivity to xenobiotic ( J:184536 )

• mice treated with T0901317 (an Lxr/Nr1h3 agonist) exhibit an attenuated increase in plasma triglycerides and cholesterol, hepatic triglycerides, biliary cholesterol, biliary cholesterol secretion and fecal neutral sterols and attenuated decrease in CAMCA bile acid composition, cholesterol absorption and hepatic cholesterol compared with control mice

liver/biliary system

increased liver weight ( J:184536 )

• in mice fed a 2% cholesterol diet

increased liver cholesterol level ( J:184536 )

• in mice fed a 2% cholesterol diet

growth/size/body

increased liver weight ( J:184536 )

• in mice fed a 2% cholesterol diet