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Phenotypes Associated with This Genotype
Genotype
MGI:5426823
Allelic
Composition
Krt16tm1(KOMP)Vlcg/Krt16tm1(KOMP)Vlcg
Genetic
Background
C57BL/6-Krt16tm1(KOMP)Vlcg
Cell Lines 10501A-A5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt16tm1(KOMP)Vlcg mutation (1 available); any Krt16 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 60% of mice die before weaning

integument
N
• mice exhibit normal nail morphology
• in weight-bearing areas
• as early as 3 weeks, mice occasionally exhibit generalized hyperkeratosis on the front paw pads and focal hyperkeratosis near the base of the tail unlike wild-type mice
• at 4 to 6 weeks, mice exhibit hyperkeratotic calluses on the glabrous parts of both front and hind paws that are restricted to areas of physical pressure unlike wild-type mice
• at 4 to 6 weeks, mice exhibit hyperkeratotic calluses on the glabrous parts of both front and hind paws that are restricted to areas of physical pressure unlike wild-type mice
• thickened epithelium in areas adjacent to calluses

growth/size/body
• at P3 mice, exhibit hypoplastic lesions in the posterior dorsal tongue epithelium along the midline unlike wild-type mice
• mice exhibit thickened epithelium compared with wild-type mice
• however, no epithelial fragility is observed
• mice exhibit loss of filiform papillae unlike wild-type mice
• throughout life
• throughout life

digestive/alimentary system
• at P3 mice, exhibit hypoplastic lesions in the posterior dorsal tongue epithelium along the midline unlike wild-type mice
• mice exhibit thickened epithelium compared with wild-type mice
• however, no epithelial fragility is observed
• mice exhibit loss of filiform papillae unlike wild-type mice

behavior/neurological
• mice spend more time resting than walking compared with wild-type mice

homeostasis/metabolism
• in weight-bearing areas

cellular
• 2-fold increase in cell proliferation of the cells in the calluses and a modest increase in uninvolved areas adjacent to calluses

craniofacial
• at P3 mice, exhibit hypoplastic lesions in the posterior dorsal tongue epithelium along the midline unlike wild-type mice
• mice exhibit thickened epithelium compared with wild-type mice
• however, no epithelial fragility is observed
• mice exhibit loss of filiform papillae unlike wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory