Mouse Genome Informatics
hm
    Krt16tm1(KOMP)Vlcg/Krt16tm1(KOMP)Vlcg
C57BL/6-Krt16tm1(KOMP)Vlcg

cell line(s): 10501A-A5
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• 60% of mice die before weaning

integument
N
• mice exhibit normal nail morphology (J:184621)
• in weight-bearing areas
• as early as 3 weeks, mice occasionally exhibit generalized hyperkeratosis on the front paw pads and focal hyperkeratosis near the base of the tail unlike wild-type mice
• at 4 to 6 weeks, mice exhibit hyperkeratotic calluses on the glabrous parts of both front and hind paws that are restricted to areas of physical pressure unlike wild-type mice
• at 4 to 6 weeks, mice exhibit hyperkeratotic calluses on the glabrous parts of both front and hind paws that are restricted to areas of physical pressure unlike wild-type mice
• thickened epithelium in areas adjacent to calluses

growth/size
• at P3 mice, exhibit hypoplastic lesions in the posterior dorsal tongue epithelium along the midline unlike wild-type mice
• mice exhibit thickened epithelium compared with wild-type mice
• however, no epithelial fragility is observed
• mice exhibit loss of filiform papillae unlike wild-type mice
• throughout life
• throughout life

digestive/alimentary system
• at P3 mice, exhibit hypoplastic lesions in the posterior dorsal tongue epithelium along the midline unlike wild-type mice
• mice exhibit thickened epithelium compared with wild-type mice
• however, no epithelial fragility is observed
• mice exhibit loss of filiform papillae unlike wild-type mice

behavior/neurological
• mice spend more time resting than walking compared with wild-type mice

homeostasis/metabolism
• in weight-bearing areas

cellular
• 2-fold increase in cell proliferation of the cells in the calluses and a modest increase in uninvolved areas adjacent to calluses

craniofacial
• at P3 mice, exhibit hypoplastic lesions in the posterior dorsal tongue epithelium along the midline unlike wild-type mice
• mice exhibit thickened epithelium compared with wild-type mice
• however, no epithelial fragility is observed
• mice exhibit loss of filiform papillae unlike wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Pachyonychia Congenita 1; PC1 167200 J:184621
Palmoplantar Keratoderma, Nonepidermolytic, Focal; FNEPPK 613000 J:184621