Phenotypes Associated with This Genotype

Genotype
MGI:5426813

• Allelic Composition: Gbp5^tm1Tigm/Gbp5^tm1Tigm
• Genetic Background: B6.Cg-Gbp5^tm1Tigm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil recruitment ( J:183942 )

• in a caspase 1-dependent model of peritonitis

• following infection with Listeria

decreased circulating interleukin-1 beta level ( J:183942 )

• following LPS-induced sepsis

decreased circulating interleukin-18 level ( J:183942 )

• following LPS-induced sepsis

decreased interleukin-1 beta secretion ( J:183942 )

• from bone marrow-derived macrophage stimulated with ATP, nigericin, muramyl dipeptide or isoglutamate diaminopimelic acid or infected with Listeria or Salmonella

• however, macrophage cells infected with Salmonella flagellin or exposed to alum and monosodium urate or dA:dT secrete normal levels of IL1b

decreased interleukin-18 secretion ( J:183942 )

• from ATP- or nigericin-stimulated bone marrow-derived macrophage

increased susceptibility to bacterial infection ( J:183942 )

• mice infected with Listeria exhibit higher bacterial burden, weight loss and reduced neutrophil recruitment compared with wild-type mice

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:183942 )

• following LPS-induced sepsis

decreased circulating interleukin-18 level ( J:183942 )

• following LPS-induced sepsis

hematopoietic system

impaired neutrophil recruitment ( J:183942 )

• in a caspase 1-dependent model of peritonitis

• following infection with Listeria