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Phenotypes Associated with This Genotype
Genotype
MGI:5426266
Allelic
Composition
Nxnl2tm1.2Tlev/Nxnl2tm1.2Tlev
Genetic
Background
BALB/c-Nxnl2tm1.2Tlev
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxnl2tm1.2Tlev mutation (0 available); any Nxnl2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• reduced S- and M-cone densities at 10 months
• at 10 months, mice exhibit reduced photopic electroretinogram of b-wave amplitude compared with wild-type mice
• however, expression of the short trophic isoform rescues cone electrophysiology
• at 10 months, mice exhibit decreased a-wave amplitudes compared with wild-type mice

taste/olfaction
• impaired olfactory discrimination with age

nervous system
• reduced S- and M-cone densities at 10 months

craniofacial

respiratory system

growth/size/body


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory