Phenotypes for Piwil2 MGI:5320672 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Piwil2^tm1.1Doca/Piwil2^tm1.1Doca
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil2^tm1.1Doca mutation (1 available); any Piwil2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell apoptosis ( J:184034 )

• 70% of mice exhibit a meiosis block in the early pachytene stage

• however, 30% of mice exhibit a slightly milder phenotype

testicular atrophy ( J:184034 )

arrest of male meiosis ( J:184034 )

male infertility ( J:184034 )

cellular

abnormal cell physiology ( J:184034 )

• mice exhibit defective piRNA biogenesis

abnormal male germ cell apoptosis ( J:184034 )

• 70% of mice exhibit a meiosis block in the early pachytene stage

• however, 30% of mice exhibit a slightly milder phenotype

abnormal DNA methylation ( J:184034 )

• mice exhibit defective CpG DNA methylation of L1 but not IAP elements in postnatal germ cells

endocrine/exocrine glands

testicular atrophy ( J:184034 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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