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Phenotypes Associated with This Genotype
Genotype
MGI:5320164
Allelic
Composition
Ptentm2.1Ppp/Ptentm2.1Ppp
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2.1Ppp mutation (0 available); any Pten mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex exhibit neurons with increased dendritic total length and branch number (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex exhibit neurons with increased dendritic total length and branch number (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex exhibit neurons with increased density of dendritic spines (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex exhibit neurons with increased density of dendritic spines (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex have neurons that exhibit lower input resistance than nearby control neurons without adenovirus (J:181347)
• pyramidal neurons from mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex receive stronger local inputs in the auditory cortex than control neurons without adenovirus; the increase is greatest for inputs arising from layer 2 but is present in all layers (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex have neurons that exhibit lower input resistance than nearby control neurons without adenovirus (J:181347)
• pyramidal neurons from mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex receive stronger local inputs in the auditory cortex than control neurons without adenovirus; the increase is greatest for inputs arising from layer 2 but is present in all layers (J:181347)
• neurons from mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex or the left auditory thalamus exhibit increased neuronal responses to auditory callosal and thalamic inputs as indicated by enhanced light-evoked EPSCs after channelrhodopsin-2 adenoviral expression (which allows for neurons to be excited to fire action potentials by flashing blue light) (J:181347)
• neurons from mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex or the left auditory thalamus exhibit increased neuronal responses to auditory callosal and thalamic inputs as indicated by enhanced light-evoked EPSCs after channelrhodopsin-2 adenoviral expression (which allows for neurons to be excited to fire action potentials by flashing blue light) (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex exhibit increased miniature spontaneous EPSC frequency and miniature EPSC amplitude (J:181347)
• mice injected with an adenovirus expressing Cre recombinase into the left auditory cortex exhibit increased miniature spontaneous EPSC frequency and miniature EPSC amplitude (J:181347)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:181347


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory