Phenotypes Associated with This Genotype

Genotype
MGI:5319646

• Allelic Composition: Tg(NPHS2-Trpc6*E896K)F75aWalz/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

albuminuria ( J:165112 )

podocyte foot process effacement ( J:165112 )

increased renal glomerulus basement membrane thickness ( J:165112 )

abnormal renal glomerulus morphology ( J:165112 )

• more severe glomeruli pathology including hypercellularity, mesangial expansion, glomerulosclerosis and collapse compared to in wild-type mice

abnormal glomerular mesangium morphology ( J:165112 )

• expanded

glomerulosclerosis ( J:165112 )

abnormal perihilar interstitium morphology ( J:165112 )

• perihilar hyalinosis

homeostasis/metabolism

albuminuria ( J:165112 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal segmental glomerulosclerosis 2		DOID:0111129	OMIM:603965	J:165112