Mouse Genome Informatics
hm
    Slc6a3tm1Hhg/Slc6a3tm1Hhg
B6.129X1-Slc6a3tm1Hhg
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• in an open-field test, mutants display higher horizontal activity than controls

nervous system
• sensitivity of cannabinoid CB1 receptors (CB1Rs) controlling GABA-mediated synaptic currents in the striatum is lost, however CB1Rs modulating glutamate transmission and GABAB receptors are not affected
• the effects of CB1R agonist HU210 on striatal neuron spontaneous inhibitory postsynaptic currents (sIPSCs) and evoked inhibitory postsynaptic currents (eIPSCs) are abolished, indicating loss of sensitivity of CB1Rs(GABA)
• however, the GABAB receptor agonist baclofen has the same effect as in controls
• cocaine or sucrose are unable to alter the HU210 effects on sIPSCs as they do in control mice
• dihydroxyphenylglycine treatment does not inhibit striatal miniature inhibitory postsynaptic current (mIPSC) frequency as in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:183177