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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a3tm1Hhg mutation (1 available); any Slc6a3 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• in an open-field test, mutants display higher horizontal activity than controls

nervous system
• sensitivity of cannabinoid CB1 receptors (CB1Rs) controlling GABA-mediated synaptic currents in the striatum is lost, however CB1Rs modulating glutamate transmission and GABAB receptors are not affected
• the effects of CB1R agonist HU210 on striatal neuron spontaneous inhibitory postsynaptic currents (sIPSCs) and evoked inhibitory postsynaptic currents (eIPSCs) are abolished, indicating loss of sensitivity of CB1Rs(GABA)
• however, the GABAB receptor agonist baclofen has the same effect as in controls
• cocaine or sucrose are unable to alter the HU210 effects on sIPSCs as they do in control mice
• dihydroxyphenylglycine treatment does not inhibit striatal miniature inhibitory postsynaptic current (mIPSC) frequency as in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Attention Deficit-Hyperactivity Disorder; ADHD 143465 J:183177

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory