Mouse Genome Informatics
hm
    Pla2g6m1J/Pla2g6m1J
C3H/HeJ-Pla2g6m1J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• astrocytes taken from 6 to 8 week old homozygotes and cultured for 14 to 16 days have diminished ATP-stimulated calcium signaling with capacitative calcium entry in these astrocytes found to be only 45% that of controls

behavior/neurological
• the first outward sign of disease is a slight tremor at approximately 50 days of age
• grip strength, assessed by the ability to hang suspended on a wire, decreases by 60-80 days and by 100 days homozygotes can no longer suspend their weight for more than a few seconds

growth/size
• Gradual weight loss begins at approximately 90 days of age and continues until premature death

mortality/aging
• homozygotes rarely survive beyond 6 month and there is only 50% survival at approximately 120 days

Mouse Models of Human Disease
OMIM IDRef(s)
Neurodegeneration with Brain Iron Accumulation 2A; NBIA2A 256600 J:183152