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Phenotypes Associated with This Genotype
Genotype
MGI:5316427
Allelic
Composition
Kiss1rtm1.1Lex/Kiss1rtm1.1Lex
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1rtm1.1Lex mutation (0 available); any Kiss1r mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• no spermatozoa are found in the lumina of the epididymis

reproductive system
• no spermatozoa are found in the lumina of the epididymis
• at 9 and 28 weeks
• frequently not identifiable
• frequently not identifiable
• reduction in the number of mature Leydig cells
• reduced length
• at 9 and 28 weeks
• severe hypogonadotropic hypogonadism
• at 9 and 28 weeks
• at 3, 9 and 28 weeks

homeostasis/metabolism
N
• mice exhibit normal gonadotropin-releasing hormone responsiveness
• female mice, but not male mice, exhibit a reduction in serum phospholipids compared with wild-type mice
• male and female mice exhibit decreased serum globulin levels compared with wild-type mice
• male and female mice exhibit an increase in the ratio of albumin to globulin compared with wild-type mice
• in female mice, but not male mice
• in male mice, but not female mice
• basal and Kp-10-stimulated luteinizing hormone levels are reduced in male mice compared to in wild-type mice
• male mice treated with NMDA, RF9 or GALP exhibit less of an increase in luteinizing hormone levels compared with wild-type mice
• following orchiectomy and testosterone treatment, male mice fail to exhibit an increase in luteinizing hormone levels in response to NMDA or RF9 unlike wild-type mice
• male mice treated with senktide fail to exhibit an increase in luteinizing hormone unlike wild-type mice
• following orchiectomy and/or testosterone treatment and withdrawal, mice fail to exhibit a change in luteinizing hormone unlike wild-type mice
• however, mice exhibit normal response to gonadotropin-releasing hormone administration and nor-BNI treatment
• in female mice, but not male mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice, but not female mice
• in female mice, but not male mice
• following gonadotropin-releasing hormone administration, mice exhibit a delay in follicle stimulating hormone levels to return to basal levels

immune system
• in male mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice

hematopoietic system
• in male mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice, but not female mice
• in male mice

growth/size/body
• in male mice, but not female mice

liver/biliary system
• in male mice

renal/urinary system
• in male and female mice
• reduced length

digestive/alimentary system

endocrine/exocrine glands
• modest decrease in adrenal gland weight in female mice
• in male mice
• frequently not identifiable
• frequently not identifiable
• at 9 and 28 weeks
• reduction in the number of mature Leydig cells
• at 3, 9 and 28 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypogonadotropic hypogonadism 8 with or without anosmia DOID:0090074 OMIM:614837
J:181650


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory