Phenotypes Associated with This Genotype

Genotype
MGI:5316221

• Allelic Composition: Atr^tm2Bal/Atr^tm2Bal; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:181920 )

• die by P7

nervous system

increased neuron apoptosis ( J:181920 )

• elevated apoptosis is detected in the external granule cell layer at E16.5

• high levels of DNA damage and elevated apoptosis in the ganglionic eminence at E15.5

abnormal neuron proliferation ( J:181920 )

• striking decrease in proliferation at E16.5 in the rhombic lip

• decrease in the size and growth of neurospheres indicating a defect in proliferation

decreased cerebellar granule cell precursor proliferation ( J:181920 )

• striking decrease in proliferation at E16.5 in the cerebellar external granule cell layer

abnormal cerebellum development ( J:181920 )

• marked defects in cerebellar development

abnormal rhombic lip morphology ( J:181920 )

• striking decrease in proliferation at E16.5 in the rhombic lip

decreased brain size ( J:181920 )

abnormal corpus callosum morphology ( J:181920 )

• decreased cellularity

abnormal cerebral cortex morphology ( J:181920 )

• decreased cellularity, especially in the upper layers

abnormal olfactory bulb granule cell layer morphology ( J:181920 )

• depleted

ectopic Purkinje cell ( J:181920 )

• mislocalization of Purkinje cells

abnormal cerebellar granule layer morphology ( J:181920 )

• defects in foliation and mislocalization of Purkinje cells

decreased cerebellar granule cell number ( J:181920 )

abnormal embryonic/fetal subventricular zone morphology ( J:181920 )

• high levels of DNA damage and elevated apoptosis in the ganglionic eminence at E15.5

growth/size/body

decreased body size ( J:181920 )

postnatal growth retardation ( J:181920 )

cellular

increased neuron apoptosis ( J:181920 )

• elevated apoptosis is detected in the external granule cell layer at E16.5

• high levels of DNA damage and elevated apoptosis in the ganglionic eminence at E15.5

abnormal neuron proliferation ( J:181920 )

• striking decrease in proliferation at E16.5 in the rhombic lip

• decrease in the size and growth of neurospheres indicating a defect in proliferation

decreased cerebellar granule cell precursor proliferation ( J:181920 )

• striking decrease in proliferation at E16.5 in the cerebellar external granule cell layer