Phenotypes Associated with This Genotype

Genotype
MGI:5315764

• Allelic Composition: Prdm8^tm1Mci/Prdm8^tm1Mci
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:182304 )

N • mice exhibit normal cortical layering

abnormal axon guidance ( J:182304 )

• in most mice, axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice

absent corpus callosum ( J:182304 )

• in most mice

absent hippocampal commissure ( J:182304 )

• in most mice

behavior/neurological

excessive scratching ( J:182304 )

• resulting in skin lesions in most mice at 6 weeks of age

abnormal motor coordination/balance ( J:182304 )

• a few mice exhibit a handstand phenotype (walking on forepaws) secondary to hindpaw contraction

integument

skin lesions ( J:182304 )

• due to excessive scratching in most mice at 6 weeks of age

cellular

abnormal axon guidance ( J:182304 )

• in most mice, axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice