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Phenotypes Associated with This Genotype
Genotype
MGI:5315439
Allelic
Composition
Atxn7tm1Hzo/Atxn7+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn7tm1Hzo mutation (1 available); any Atxn7 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants with 100 CAG repeats exhibit a shorter lifespan than wild-type mice, with an average of 18.7 months
• mutants with 230 CAG repeats have an average lifespan of only 3.5 months

growth/size/body
• in mutants with 100 and 230 CAG repeats

behavior/neurological
• in mutants with 100 and 230 CAG repeats
• gradual loss of mobility in mutants with 100 and 230 CAG repeats
• mutants with 100 and 230 CAG repeats progressively develop mild ataxia

skeleton
• in mutants with 100 and 230 CAG repeats

vision/eye
• in mutants with 100 and 230 CAG repeats

Mouse Models of Human Disease
OMIM ID Ref(s)
Spinocerebellar Ataxia 7; SCA7 164500 J:179021


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory