Mouse Genome Informatics
ht
    Atxn7tm1Hzo/Atxn7+
involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mutants with 100 CAG repeats exhibit a shorter lifespan than wild-type mice, with an average of 18.7 months
• mutants with 230 CAG repeats have an average lifespan of only 3.5 months

growth/size/body
• in mutants with 100 and 230 CAG repeats

behavior/neurological
• in mutants with 100 and 230 CAG repeats
• gradual loss of mobility in mutants with 100 and 230 CAG repeats
• mutants with 100 and 230 CAG repeats progressively develop mild ataxia

skeleton
• in mutants with 100 and 230 CAG repeats

vision/eye
• in mutants with 100 and 230 CAG repeats

Mouse Models of Human Disease
OMIM IDRef(s)
Spinocerebellar Ataxia 7; SCA7 164500 J:179021