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Phenotypes Associated with This Genotype
Genotype
MGI:5314999
Allelic
Composition
Tmc1stitch/Tmc1stitch
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1stitch mutation (0 available); any Tmc1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at 4 weeks of age, the inner row of stereocilia of the OHC hair bundle is often irregular in length or missing
• loss of inner hair cells in the basal turn at 8 weeks of age
• loss of outer hair cells in the basal turn at 8 weeks of age
• at 4 weeks of age slight indications of hair cell degeneration are seen
• at 8 weeks, but not at 4 weeks, of age the basal region lacks sensory or supporting cells and the organ/tunnel of Corti has collapsed
• display a hearing loss ranging from 60 to 120 dB SPL at 4 weeks of age

behavior/neurological
N
• no circling or head tossing/tilting behaviors are seen

nervous system
• at 4 weeks of age, the inner row of stereocilia of the OHC hair bundle is often irregular in length or missing
• loss of inner hair cells in the basal turn at 8 weeks of age
• loss of outer hair cells in the basal turn at 8 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Deafness, Autosomal Recessive 7; DFNB7 600974 J:181985


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory