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Phenotypes Associated with This Genotype
Genotype
MGI:5314953
Allelic
Composition
Eif4hGt(Ex279)Byg/Eif4hGt(Ex279)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4hGt(Ex279)Byg mutation (0 available); any Eif4h mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• female mice produce smaller than normal litters, none of which survive (J:181945)
• female mice produce smaller than normal litters, none of which survive (J:181945)
• female mice mated to wild-type male mice produce smaller than normal litters, no of which survive (J:181945)
• female mice mated to wild-type male mice produce smaller than normal litters, no of which survive (J:181945)
(J:181945)
(J:181945)

nervous system
• reduced brainstem volume (J:181945)
• reduced brainstem volume (J:181945)
• reduced posterior cerebrum (posterior cortex, thalamic and hypothalamic nuclei) volume (J:181945)
• however, hippocampus size is preserved (J:181945)
• reduced posterior cerebrum (posterior cortex, thalamic and hypothalamic nuclei) volume (J:181945)
• however, hippocampus size is preserved (J:181945)
• reduced branching and spine number (J:181945)
• reduced branching and spine number (J:181945)
• reduced (J:181945)
• reduced (J:181945)
• in the posterior cerebral cortex (J:181945)
• in the posterior cerebral cortex (J:181945)

skeleton
• decreased skeleton and skull volume (J:181945)
• decreased skeleton and skull volume (J:181945)
• decreased anteroposterior skull axis (J:181945)
• decreased anteroposterior skull axis (J:181945)
• decreased anteroposterior skull axes (J:181945)
• decreased anteroposterior skull axes (J:181945)

growth/size/body
• after 1 week of age (J:181945)
• after 1 week of age (J:181945)

behavior/neurological
N
• mice exhibit normal motor coordination (J:181945)
• mice exhibit normal motor coordination (J:181945)
• mice exhibit reduced freezing in delay and trace fear conditioning tasks compared with wild-type mice (J:181945)
• mice exhibit reduced freezing in delay and trace fear conditioning tasks compared with wild-type mice (J:181945)
• in a Morris water maze (J:181945)
• in a Morris water maze (J:181945)
• in response to a novel object (J:181945)
• in response to a novel object (J:181945)

adipose tissue

craniofacial
• decreased anteroposterior skull axis (J:181945)
• decreased anteroposterior skull axis (J:181945)
• decreased anteroposterior skull axes (J:181945)
• decreased anteroposterior skull axes (J:181945)

muscle
• decreased muscle volume (J:181945)
• decreased muscle volume (J:181945)
• on a rotarod (J:181945)
• on a rotarod (J:181945)

other phenotype
• no offspring born to mated female mice survive (J:181945)
• no offspring born to mated female mice survive (J:181945)

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:181945


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory