Mouse Genome Informatics
hm
    Eif4hGt(Ex279)Byg/Eif4hGt(Ex279)Byg
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• female mice produce smaller than normal litters, none of which survive (J:181945)
• female mice mated to wild-type male mice produce smaller than normal litters, no of which survive
(J:181945)

nervous system
• reduced brainstem volume
• reduced posterior cerebrum (posterior cortex, thalamic and hypothalamic nuclei) volume
• however, hippocampus size is preserved
• reduced branching and spine number
• in the posterior cerebral cortex

skeleton
• decreased skeleton and skull volume
• decreased anteroposterior skull axis
• decreased anteroposterior skull axes

growth/size
• after 1 week of age

behavior/neurological
N
• mice exhibit normal motor coordination (J:181945)
• mice exhibit reduced freezing in delay and trace fear conditioning tasks compared with wild-type mice
• in a Morris water maze
• in response to a novel object

adipose tissue

craniofacial
• decreased anteroposterior skull axis
• decreased anteroposterior skull axes

muscle
• decreased muscle volume
• on a rotarod

other phenotype
• no offspring born to mated female mice survive

Mouse Models of Human Disease
OMIM IDRef(s)
Williams-Beuren Syndrome; WBS 194050 J:181945