homeostasis/metabolism
• slight and insignificantly delayed appearance of small thrombi
• vessel occlusion is delayed or absent
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• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets
• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used
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hematopoietic system
• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets
• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used
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cardiovascular system
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice
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• brain hemorrhages at E12.5
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respiratory system
N |
• at P0, mice exhibit normal lungs
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immune system
• at E14.5, mice exhibit blood-filled vessels unlike control mice
• at 6 to 8 weeks, mice exhibit blood in mesenteric and intestinal lymphatic vessels and intestine proper unlike in control mice
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice
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• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets
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nervous system
• brain hemorrhages at E12.5
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