Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
• mutants exhibit a higher degree of thigmotaxis in the inescapable open field than wild-type mice
• however, mutants are indistinguishable in anxiety-related behaviors in the elevated plus maze from wild-type mice
• mutants initially exhibit higher levels of contact with a novel, non-mouse object compared with wild-type mice
• mutants exhibit lower levels of spontaneous alternations in the T-maze at 0 and 30 second delays compared to wild-type mice; both wild-type and mutant mice reach a chance level at a 60 second delay
• in the T-maze, mutants visit the same arms across trials more often than wild-type mice when mutants show spontaneous alternation (0 second delay) but not when they do not show spontaneous alternation at a 60 second delay, indicating a repetitive behavioral tendency
• mutants exhibit lower levels of active and passive affiliative social interaction at 2 months of age, but no alterations in aggression, olfactory investigation or motor behavior
• mutant pups are impaired in complex patterns of vocalization but not simple vocal patterns
• pups exhibit vocalization less frequently in complex, two-syllable, composite, frequency steps and flat, and for shorter duration in harmonics, two-syllable, composite, and frequency steps

Mouse Models of Human Disease
Autism 209850 J:177772