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Phenotypes Associated with This Genotype
Genotype
MGI:5313999
Allelic
Composition
Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+
Genetic
Background
involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cigs2tm1.1Anse mutation (0 available); any Cigs2 mutation (0 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• following intraperitoneal injection of ovalbumin, mice exhibit normal IgG2b response compared with Il4tm1(CD2)Mmrs heterozygotes
• T cells and basophils exhibit normal Il13 production
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
• in Th2 polarized CD4+ T cells compared with Il4tm1(CD2)Mmrs heterozygotes
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

hematopoietic system
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory