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Phenotypes Associated with This Genotype
Genotype
MGI:5313997
Allelic
Composition		 Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes
decreased IgE level ( J:178986 )
• in mice infected with Nippostrongylus brasiliensis
decreased IgG1 level ( J:178986 )
• in an anti-NP response
decreased interleukin-4 secretion ( J:181313 )
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes
decreased IgE level ( J:178986 )
• in mice infected with Nippostrongylus brasiliensis
decreased IgG1 level ( J:178986 )
• in an anti-NP response

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory