Mouse Genome Informatics
ht
    Fbn1tm3.2Lysa/Fbn1+
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice

integument
• mice exhibit thickened and less elastic skin compared to in wild-type mice
• excessive collagen deposition
• persisting through old age

limbs/digits/tail
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age

adipose tissue

cardiovascular system
N
• in contrast to Fbn1-targeted mouse models of Marfan Syndrome, aortic root morphology is normal (J:181493)

skeleton
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Marfan Syndrome; MFS 154700 J:181493
Weill-Marchesani Syndrome 2; WMS2 608328 J:181493