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Phenotypes Associated with This Genotype
Genotype
MGI:5313384
Allelic
Composition
Fbn1tm3.2Lysa/Fbn1+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm3.2Lysa mutation (0 available); any Fbn1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice

integument
• mice exhibit thickened and less elastic skin compared to in wild-type mice
• excessive collagen deposition
• persisting through old age

limbs/digits/tail
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age

adipose tissue

cardiovascular system
N
• in contrast to Fbn1-targeted mouse models of Marfan Syndrome, aortic root morphology is normal

skeleton
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Marfan Syndrome; MFS 154700 J:181493
Weill-Marchesani Syndrome 2; WMS2 608328 J:181493


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory