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Phenotypes Associated with This Genotype
Genotype
MGI:5312616
Allelic
Composition
Myo7ash1-11J/Myo7ash1-11J
Genetic
Background
129.B6-Myo7ash1-11J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo7ash1-11J mutation (1 available); any Myo7a mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months

vision/eye
• mutants exposed to moderate intensity light show an accumulation of superoxide in rods at a level 3.5 times greater than in wild-type mice
• mutants exhibit rod photoreceptor degeneration in response to moderate intensity light exposure that is not seen in wild-type mice
• mutants reared under a moderate light/dark cycle, but not dim/dark cycle conditions, develop severe retinal degeneration in less than 6 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Usher Syndrome, Type I; USH1 276900 J:181430


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory