Mouse Genome Informatics
tg
    Tg(Thy1-TARDBP*)BOddo/0
C57BL/6-Tg(Thy1-TARDBP*)BOddo
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mutants do not exhibit motor dysfunction, and show normal spontaneous activity, open-field thigmotaxis, time spent in the center of the arena, and rotarod performance (J:180165)
• in the novel object recognition task, mutants at 6 months of age, did not discriminate between the novel and old object as in controls, indicating impaired cortical and hippocampal function
• mutants exhibit impaired performance on the T-maze at 6 months, but not 2 months of age, indicating impaired working memory

Mouse Models of Human Disease
OMIM IDRef(s)
Frontotemporal Lobar Degeneration with Tdp43 Inclusions, Grn-Related 607485 J:180165