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Phenotypes Associated with This Genotype
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phenotype observed in females
phenotype observed in males
N normal phenotype
• 6 month old mutants do not exhibit motor dysfunction, and show normal spontaneous activity, open-field thigmotaxis, time spent in the center of the arena, and rotarod performance
• in the novel object recognition task, mutants at 6 months of age, did not discriminate between the novel and old object as in controls, indicating impaired cortical and hippocampal function
• 15 month old mice perform worse than wild-type mice on the Morris water maze on day 2-4, traveling longer distances to find the hidden platform and spending less time in the target quadrant
• 15 month old mutants perform worse than controls in the radial arm water maze showing more entries in arms without platform on day 2, indicating impaired spatial memory
• mutants exhibit impaired performance on the T-maze at 6 months, but not 2 months of age, indicating impaired working memory
• 15 month old mice perform worse than wild-type controls on the rotard and the accelerated rotarod

• marker analysis indicates that autophagy induction is reduced in 15 month old mice

• 15 month old mice show a decrease in chymotrypsin-like, trypsin-like, and caspase-like activities of the proteasome in the brain, indicating a decrease in proteasome function

nervous system
• 15 month old mice mice show increased soluble levels of the 25 kDa C-terminal fragment of TARDBP in the nucleus and cytosol

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory