Phenotypes Associated with This Genotype

Genotype
MGI:5310794

• Allelic Composition: Slc22a3^tm1Dpb/Slc22a3^tm1Dpb
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• paraquat-treated mice exhibit increased striatal neurotoxicity, decreased striatal dopamine and increased dopamine overflow compared with similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• paraquat-treated mice exhibit increased striatal neurotoxicity, decreased striatal dopamine and increased dopamine overflow compared with similarly treated wild-type mice

abnormal dopamine level ( J:180517 )

• paraquat-treated mice exhibit decreased striatal dopamine but increased dopamine overflow compared with similarly treated wild-type mice

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:180517 )

• paraquat-treated mice exhibit increased striatal neurotoxicity, decreased striatal dopamine and increased dopamine overflow compared with similarly treated wild-type mice