Mouse Genome Informatics
ot
    Mecp2tm1.1Joez/Y
B6.129-Mecp2tm1.1Joez
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die by 16 weeks of age

behavior/neurological
• mice exhibit RTT-like symptoms after 5 weeks of age
• in an elevated zero maze
• impaired motor learning on a rotarod
• at 13 weeks of age
• on a rotarod
• not as severe as in Mecp2tm1.1Jae hemizygotes
• at 11, but not 3, weeks of age
• not as severe as in Mecp2tm1.1Jae hemizygotes
• with splaying hind limbs upon movement
• occasionally after 5 weeks of age

nervous system
• occasionally after 5 weeks of age
• at P30 and P90
• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice
• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice
• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice
• however, mice exhibit normal power and event-related potential at P30

growth/size/body
• between 4 and 8 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:181311