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Phenotypes Associated with This Genotype
Genotype
MGI:5310735
Allelic
Composition
Mecp2tm1.1Joez/Y
Genetic
Background
B6.129-Mecp2tm1.1Joez
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Joez mutation (1 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die by 16 weeks of age (J:181311)
• 50% of mice die by 16 weeks of age (J:181311)

behavior/neurological
• mice exhibit RTT-like symptoms after 5 weeks of age (J:181311)
• mice exhibit RTT-like symptoms after 5 weeks of age (J:181311)
• in an elevated zero maze (J:181311)
• in an elevated zero maze (J:181311)
• impaired motor learning on a rotarod (J:181311)
• impaired motor learning on a rotarod (J:181311)
• at 13 weeks of age (J:181311)
• at 13 weeks of age (J:181311)
• on a rotarod (J:181311)
• not as severe as in Mecp2tm1.1Jae hemizygotes (J:181311)
• on a rotarod (J:181311)
• not as severe as in Mecp2tm1.1Jae hemizygotes (J:181311)
(J:181311)
(J:181311)
• at 11, but not 3, weeks of age (J:181311)
• not as severe as in Mecp2tm1.1Jae hemizygotes (J:181311)
• at 11, but not 3, weeks of age (J:181311)
• not as severe as in Mecp2tm1.1Jae hemizygotes (J:181311)
• with splaying hind limbs upon movement (J:181311)
• with splaying hind limbs upon movement (J:181311)
• occasionally after 5 weeks of age (J:181311)
• occasionally after 5 weeks of age (J:181311)

nervous system
• occasionally after 5 weeks of age (J:181311)
• occasionally after 5 weeks of age (J:181311)
• at P30 and P90 (J:181311)
• at P30 and P90 (J:181311)
• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice (J:181311)
• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice (J:181311)
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice (J:181311)
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice (J:181311)
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice (J:181311)
• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice (J:181311)
• however, mice exhibit normal power and event-related potential at P30 (J:181311)
• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice (J:181311)
• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice (J:181311)
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice (J:181311)
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice (J:181311)
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice (J:181311)
• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice (J:181311)
• however, mice exhibit normal power and event-related potential at P30 (J:181311)

growth/size/body
• between 4 and 8 weeks of age (J:181311)
• between 4 and 8 weeks of age (J:181311)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:181311


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory