Phenotypes Associated with This Genotype

Genotype
MGI:5308806

• Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a⁺; Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 34.2 weeks

• 43% of tumors exhibit sarcomatoid differentiation

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 57% of tumors exhibit well differentiated ductal adenocarcinoma histology

increased metastatic potential ( J:108298 )

• 69% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 34.2 weeks

• 43% of tumors exhibit sarcomatoid differentiation

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 57% of tumors exhibit well differentiated ductal adenocarcinoma histology