Phenotypes Associated with This Genotype

Genotype
MGI:5308467

• Allelic Composition: Chrna4^tm1.1Stit/Chrna4^tm1.1Stit
• Genetic Background: B6.129X1-Chrna4^tm1.1Stit

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:180872 )

N • nicotine-treated mice exhibit normal activity in a Y-maze

abnormal behavioral response to addictive substance ( J:180872 )

• mice exhibit reduced consumption of nicotine compared with wild-type mice

impaired conditioned place preference behavior ( J:180872 )

• mice do not develop place preference to nicotine unlike wild-type mice

homeostasis/metabolism

decreased body temperature ( J:180872 )

• induced by nicotine