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Phenotypes Associated with This Genotype
Genotype
MGI:5308013
Allelic
Composition
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic
Background
B6.Cg-Tg(ED-L2-IL1RN/IL1B)#Tcw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• at 6 months of age profound epithelial hyperplasia is seen in the squamocolumnar junction
• at 12-15 months of age, 90% of mice display severe columnar metaplasia with mucus producing cells in the squamocolumnar junction
• treatment with 0.2% deoxycholate accelerates the development of Barrett-like metaplasia in the squamocolumnar junction
• at 20-22 months of age about 20% of mice develop high-grade dysplasia or intramucosal esophageal adenocarcinoma
• at 20-22 months of age lesions are grossly visible within the distal end of the esophagus
• mutant esophagi show circumferential erythema and edema with inflammatory exudates compared to the normal esophagus and changes are made more severe by treatment with 0.2% deoxycholate
• expansion of gastric cardia progenitor cells in the esophagus over time
• markedly thickened
• markedly thickened with a mix of acute and chronic inflammatory infiltrate
• markedly thickened forestomach with a mix of acute and chronic inflammatory infiltrate
• increase in proliferation in the esophageal basal compartment
• mix of acute and chronic inflammatory infiltrate
• treatment with 0.2% deoxycholate induced more severe esophagitis with inflammatory infiltrates in mutant mice compared to wild-type controls

neoplasm
• mice treated with 0.2% deoxycholate and N-methyl-N-nitrosourea show increased esophageal tumor development compared to wild-type controls
• at 20-22 months of age about 20% of mice develop high-grade dysplasia or intramucosal esophageal adenocarcinoma
• during the stepwise progression to cancer there is a gradual increase in alpha SMA+ stromal myofibroblasts and increasing stroma global hypomethylation

immune system
• elevated IL6 in the tongue, esophagus, and forestomach but not in the stomach
• mix of acute and chronic inflammatory infiltrate in the forestomach
• at 6 months of age moderate inflammation is seen in the squamocolumnar junction
• mix of acute and chronic inflammatory infiltrate
• treatment with 0.2% deoxycholate induced more severe esophagitis with inflammatory infiltrates in mutant mice compared to wild-type controls

homeostasis/metabolism
• elevated IL6 in the tongue, esophagus, and forestomach but not in the stomach
• mice treated with 0.2% deoxycholate and N-methyl-N-nitrosourea show increased esophageal tumor development compared to wild-type controls

growth/size/body
• at 20-22 months, associated with gross esophageal lesions

hematopoietic system

Mouse Models of Human Disease
OMIM ID Ref(s)
Barrett Esophagus 614266 J:180282
Esophageal Cancer 133239 J:180282


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory