About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5307894
Allelic
Composition
Tnfsf11tles/Tnfsf11tles
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11tles mutation (2 available); any Tnfsf11 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in culture, osteoblasts fail to produce adequate crosstalk to promote differentiation of wild-type hematopoietic progenitors into osteoclasts

mortality/aging
• most mice die by the seventh week of age

skeleton
N
• bone marrow exposed to wild-type osteoblasts exhibits normal differentiation into osteoclasts
• in culture, osteoblasts fail to produce adequate crosstalk to promote differentiation of wild-type hematopoietic progenitors into osteoclasts
• absent
• however, treatment with TNFSF11 restores osteoclast formation
• trabecular spacing is reduced compared to in wild-type mice
• severe

immune system
• absent
• however, treatment with TNFSF11 restores osteoclast formation

growth/size/body

craniofacial

hematopoietic system
• absent
• however, treatment with TNFSF11 restores osteoclast formation

endocrine/exocrine glands

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive osteopetrosis 2 DOID:0110943 OMIM:259710
J:179743


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/31/2020
MGI 6.15
The Jackson Laboratory