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Phenotypes Associated with This Genotype
Genotype
MGI:5307257
Allelic
Composition
Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Brn mutation (2 available); any Brca1 mutation (73 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (147 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

tumorigenesis
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
• compared to KB1C61GP littermate controls
• in transplanted tumors response to olaparib treatment is improved compared to KB1C61GP littermate controls and KP mice
• transplanted tumors never develop resistance to cisplatin unlike tumors from KP mice
• increased genomic instability in tumors compared to mice homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)
• median latency is 236 days compared to 197 days in littermate controls heterozygous for Brca1tm1Brn and Brca1tm1.1Jjon, homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1C61GP)

integument
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
• compared to KB1C61GP littermate controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:178595


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory