Mouse Genome Informatics
cn
    Brca1tm1Brn/Brca1tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0

involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• compared to KB1C61GP littermate controls
• in transplanted tumors response to olaparib treatment is improved compared to KB1C61GP littermate controls and KP mice
• transplanted tumors never develop resistance to cisplatin unlike tumors from KP mice
• increased genomic instability in tumors compared to mice homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
• median latency is 236 days compared to 197 days in littermate controls heterozygous for Brca1tm1Brn and Brca1tm1.1Jjon, homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1C61GP)

integument
• compared to KB1C61GP littermate controls

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:178595