Analysis Tools
mortality/aging
|
• mice die within 3 to 4 hours after birth and/or were devoured by the mother
|
integument
|
• at birth and at E18.5 detected by increased dye penetration and 2-fold increase in total evaporative water loss
|
|
• mice lack ultra-long-chain acyl ceramides
• the lipid barrier is disrupted
• however, the corneocyte plasma membrane structure is conserved
|
|
• twice as thick as in wild-type mice
|
|
• corneodesmosomes and the periderm persist in the stratum corneum due to defective cornification
|
|
• lamellar body biogenesis and extrusion are accelerated compared to in wild-type mice
|
|
• skin is unwrinkled, erythematous and sticky
|
reddish skin
(
J:179754
)
|
• mice exhibit arrested epidermal maturation at the embryonic pe-barrier stage
• cornified envelope assembly is impaired at the late steps
|
|
• delayed cornification
|
homeostasis/metabolism
dehydration
(
J:179754
)
|
• at birth and at E18.5 detected by increased dye penetration and 2-fold increase in total evaporative water loss
|
|
• mice lack ultra-long-chain acyl ceramides
|
behavior/neurological
|
• due to maternal rejection
|
growth/size/body
|
• due to desiccation
|
immune system
|
• in E18.5 mice exposed to Candida albicans
|
