Phenotypes Associated with This Genotype

Genotype
MGI:5307142

• Allelic Composition: Cacng8^tm1.1Suto/Cacng8^tm1.1Suto
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:179775 )

N • mice are viable

reproductive system

abnormal reproductive system physiology ( J:179775 )

• mice exhibit difficulty breeding when using homozygotes

nervous system

nervous system phenotype ( J:179775 )

N • mice exhibit normal paired-pulse ratio and long term potentiation

abnormal excitatory postsynaptic currents ( J:179775 )

• the ratio of AMPAR-mediated to NMDAR-mediated excitatory postsynaptic currents is reduced compared to in wild-type mice

abnormal glutamate-mediated receptor currents ( J:179775 )

• the ratio of AMPAR-mediated to NMDAR-mediated excitatory postsynaptic currents is reduced compared to in wild-type mice

abnormal AMPA-mediated synaptic currents ( J:179775 )

• the AMPA-evoked whole-cell currents are reduced compared to in wild-type mice

• however, mice exhibit normal I-V relationship of synaptic AMPARs