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Phenotypes Associated with This Genotype
Genotype
MGI:5307127
Allelic
Composition
Wastm1Sbs/Wastm1Sbs
Genetic
Background
129S6/SvEvTac-Wastm1Sbs/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wastm1Sbs mutation (2 available); any Was mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mutants older than 6 months of age exhibit proteinuria

immune system
• elevation in serum IgA, both in young and old mutants
• B cells exhibit increased IgA production after stimulation with LPS, TGF-beta1, IL-4, and IL-5
• reduced ratio of sialylated and galactosylated IgA in the serum, indicating that glycosylation of IgA is abnormal in mutants
• mutants exhibit higher titers of circulating IgA-containing complexes
• mutants exhibit increased glomerular IgA deposition in the kidneys
• mutants exhibit increased glomerular IgM and C3 complement deposition in the kidneys
• mutants develop proliferative glomerulonephritis similar to human IgA nephropathy

renal/urinary system
• mutants older than 6 months of age exhibit proteinuria
• mutants exhibit renal injury with increasing severity with advancing age
• mutants develop proliferative glomerulonephritis similar to human IgA nephropathy
• mutants older than 6 months of age exhibit hump-like mesangial and paramesangial deposits
• mutants older than 6 months of age, exhibit increased mesangial cellularity with or without endocapillary proliferation
• mutants older than 6 months of age, exhibit increased matrix deposition with or without endocapillary proliferation

hematopoietic system
• elevation in serum IgA, both in young and old mutants
• B cells exhibit increased IgA production after stimulation with LPS, TGF-beta1, IL-4, and IL-5
• reduced ratio of sialylated and galactosylated IgA in the serum, indicating that glycosylation of IgA is abnormal in mutants
• mutants exhibit higher titers of circulating IgA-containing complexes
• mutants exhibit increased glomerular IgA deposition in the kidneys
• mutants exhibit increased glomerular IgM and C3 complement deposition in the kidneys


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory