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Phenotypes Associated with This Genotype
Genotype
MGI:5307125
Allelic
Composition
Pex11btm1Sjg/Pex11b+
Genetic
Background
B6.129-Pex11btm1Sjg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pex11btm1Sjg mutation (0 available); any Pex11b mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• primary neuronal cultures from the neocortex and cerebellum exhibit higher levels of apoptosis than wild-type cultures but not as high as in homozygous cultures
• mutants exhibit a higher number of TUNEL-positive neurons in the medial neocortex and cerebellumthan wild-type mice, although levels are much lower than in homozygotes
• marker analysis indicates that mutants exhibit a delay in neuronal differentiation, but to a smaller extent than in homozygotes
• mutants exhibit an increase in oxidative stress in brain sections and primary neural cultures, but less than in homozygotes

nervous system
• primary neuronal cultures from the neocortex and cerebellum exhibit higher levels of apoptosis than wild-type cultures but not as high as in homozygous cultures
• mutants exhibit a higher number of TUNEL-positive neurons in the medial neocortex and cerebellumthan wild-type mice, although levels are much lower than in homozygotes
• marker analysis indicates that mutants exhibit a delay in neuronal differentiation, but to a smaller extent than in homozygotes
• brain sections from E19 fetuses exhibit a 15% increase in the number of peroxisomes/area in the cerebellum and medial neocortex
• brain sections from E19 fetuses exhibit a 15% increase in the number of peroxisomes/area in the cerebellum and medial neocortex

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Zellweger syndrome DOID:905 J:180632


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory