About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5306390
Allelic
Composition
Eif2b5tm1Itl/Eif2b5tm1Itl
Genetic
Background
involves: 129S/SvEv * C57BL * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2b5tm1Itl mutation (0 available); any Eif2b5 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• abnormal development of brain white matter
• as detected by MRI
• however, older mice exhibit normal isotropy values in an MRI
• decreased astrocyte numbers at 3 weeks but not 4 months
• at 3 weeks but not 4 months
• young mice exhibit a higher portion of small-caliber axons compared with wild-type mice
• late-onset myelin degeneration
• impaired recovery from cuprizone-induced demyelination

homeostasis/metabolism
• impaired recovery from cuprizone-induced demyelination

adipose tissue

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
leukoencephalopathy with vanishing white matter DOID:0060868 OMIM:603896
J:179801


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/15/2019
MGI 6.14
The Jackson Laboratory