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Phenotypes Associated with This Genotype
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

nervous system
• decrease size of CA2 neurons
• decreased size of the olfactory glomeruli
• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice
• at P90, mice exhibit less of an increase in event related phase-locking factor compared with wild-type mice

• impaired motor learning on a rotarod
• in an elevated zero maze
• on a rotarod
• develops at 6 weeks of age
• with splaying hind limbs upon movement

Mouse Models of Human Disease
OMIM ID Ref(s)
Rett Syndrome; RTT 312750 J:106973

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory