Mouse Genome Informatics
ot
    Mecp2tm1.1Jae/Y
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
(J:106973)

nervous system
• decrease size of CA2 neurons (J:106973)
• decreased size of the olfactory glomeruli (J:106973)
• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls (J:106973)
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice (J:181311)
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice (J:181311)
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice (J:181311)
• at P90, mice exhibit less of an increase in event related phase-locking factor compared with wild-type mice (J:181311)

behavior/neurological
• in an elevated zero maze (J:181311)
• impaired motor learning on a rotarod (J:181311)
• on a rotarod (J:181311)
(J:181311)
• develops at 6 weeks of age (J:106973)
• with splaying hind limbs upon movement (J:181311)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:106973