About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5304716
Allelic
Composition
Gt(ROSA)26Sortm4(HIF2A*)Kael/Gt(ROSA)26Sor+
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(HIF2A*)Kael mutation (1 available); any Gt(ROSA)26Sor mutation (572 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system

cardiovascular system
• at 8 and 11 weeks, mice exhibit increased left ventricular end-diastolic dimension compared with control mice
• at 8 and 11 weeks
• 8 week old mice show signs of dilated cardiomyopathy including left ventricle dilatation and decreased fractional shortening
• at 8 and 11 weeks, mice exhibit reduced fractional shortening compared with control mice

respiratory system

muscle
• 8 week old mice show signs of dilated cardiomyopathy including left ventricle dilatation and decreased fractional shortening
• at 8 and 11 weeks, mice exhibit reduced fractional shortening compared with control mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:179490


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/06/2021
MGI 6.16
The Jackson Laboratory