Phenotypes Associated with This Genotype

Genotype
MGI:5304716

• Allelic Composition: Gt(ROSA)26Sor^{tm4(HIF2A*)Kael}/Gt(ROSA)26Sor⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver vascular congestion ( J:179490 )

cardiovascular system

liver vascular congestion ( J:179490 )

pulmonary vascular congestion ( J:179490 )

increased angiogenesis ( J:179490 )

abnormal heart left ventricle morphology ( J:179490 )

• at 8 and 11 weeks, mice exhibit increased left ventricular end-diastolic dimension compared with control mice

cardiac fibrosis ( J:179490 )

• at 8 and 11 weeks

dilated cardiomyopathy ( J:179490 )

• 8 week old mice show signs of dilated cardiomyopathy including left ventricle dilatation and decreased fractional shortening

decreased ventricle muscle contractility ( J:179490 )

• at 8 and 11 weeks, mice exhibit reduced fractional shortening compared with control mice

respiratory system

pulmonary vascular congestion ( J:179490 )

muscle

dilated cardiomyopathy ( J:179490 )

• 8 week old mice show signs of dilated cardiomyopathy including left ventricle dilatation and decreased fractional shortening

decreased ventricle muscle contractility ( J:179490 )

• at 8 and 11 weeks, mice exhibit reduced fractional shortening compared with control mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cardiomyopathy		DOID:0050700		J:179490