Phenotypes Associated with This Genotype

Genotype
MGI:5302098

• Allelic Composition: Dpp6^tm1.1Dahn/Dpp6^tm1.1Dahn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal afterhyperpolarization ( J:178547 )

• enhanced due to slower A-current inactivation during repolarization

abnormal synaptic transmission ( J:178547 )

• CA1 pyramidal neuron apical dendrites are hyperexcitable compared with wild-type neurons

• however, somatic membrane excitability and GABAergic currents are normal

abnormal long-term potentiation ( J:178547 )

• neurons exhibit extended spike-timing window for long term potentiation compared with wild-type neurons

abnormal channel response ( J:178547 )

• mice lack the distal dendritic A-type potassium current gradient compared with wild-type mice

• calcium electrogenesis is enhanced in CA1 dendrites compared to in wild-type cells

• remaining A-type potassium channels in dendrites are Kcna4 mediated