Phenotypes Associated with This Genotype

Genotype
MGI:5301617

• Allelic Composition: Atxn1^tm1Hzo/Atxn1^tm1Hzo; Atxn1l^tm2.1Hzo/Atxn1l^tm2.1Hzo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:178303 )

• about 73% of pups die within 3 h of birth

postnatal lethality, complete penetrance ( J:178303 )

• all die before weaning

homeostasis/metabolism

cyanosis ( J:178303 )

• about 73% of pups of cyanotic and die within 3 h of birth

growth/size/body

omphalocele ( J:178303 )

• in about 45% of embryos

nervous system

enlarged lateral ventricles ( J:178303 )

• at birth in most pups

enlarged third ventricle ( J:178303 )

• at birth in most pups