Mouse Genome Informatics
ht
    Cxcr4tm1.1Bala/Cxcr4+
B6.129S2-Cxcr4tm1.1Bala
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• increased number of recirculating mature B cells
• in the bone marrow and lymph nodes
• relative number of circulating cells is increased
• 80% fewer leukocytes than in controls
• decreased number of circulating B cells
• decrease in pro/pre-B cells
• in the blood and spleen
• absolute numbers of all T cell types is reduced
• relative number of circulating cells is increased
• 30% reduction in thymus cellularity
• 45% lower spleen cellularity
• 20% lower spleen weight
• marginal zone B cell numbers are maintained but all other types are reduced
• increased total cell count in lymph nodes
• disorganized lymph node architecture
• "high endothelial venule" predominantly localized to T cell zones but with a scattered distribution
• absence of B-cell follicles
• NK cells exhibit increased migration to CXCL12 gradients compared with wild-type cells

cellular
• increased sensitivity of leukocytes to CXCL12 induced chemotaxis

hematopoietic system
• 30% reduction in thymus cellularity
• increased number of recirculating mature B cells
• in the bone marrow and lymph nodes
• relative number of circulating cells is increased
• 80% fewer leukocytes than in controls
• decreased number of circulating B cells
• decrease in pro/pre-B cells
• in the blood and spleen
• absolute numbers of all T cell types is reduced
• relative number of circulating cells is increased
• 45% lower spleen cellularity
• 20% lower spleen weight
• marginal zone B cell numbers are maintained but all other types are reduced
• NK cells exhibit increased migration to CXCL12 gradients compared with wild-type cells

endocrine/exocrine glands
• 30% reduction in thymus cellularity

Mouse Models of Human Disease
OMIM IDRef(s)
WHIM Syndrome 193670 J:186735