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Phenotypes Associated with This Genotype
Genotype
MGI:5301555
Allelic
Composition
Cxcr4tm1.1Bala/Cxcr4+
Genetic
Background
B6.129S2-Cxcr4tm1.1Bala
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm1.1Bala mutation (0 available); any Cxcr4 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• relative number of circulating cells is increased
• increased number of recirculating mature B cells
• in the bone marrow and lymph nodes
• relative number of circulating cells is increased
• 80% fewer leukocytes than in controls
• decreased number of circulating B cells
• decrease in pro/pre-B cells
• in the blood and spleen
• absolute numbers of all T cell types is reduced
• 30% reduction in thymus cellularity
• 45% lower spleen cellularity
• 20% lower spleen weight
• marginal zone B cell numbers are maintained but all other types are reduced
• increased total cell count in lymph nodes
• disorganized lymph node architecture
• "high endothelial venule" predominantly localized to T cell zones but with a scattered distribution
• absence of B-cell follicles
• NK cells exhibit increased migration to CXCL12 gradients compared with wild-type cells

cellular
• increased sensitivity of leukocytes to CXCL12 induced chemotaxis

hematopoietic system
• 30% reduction in thymus cellularity
• relative number of circulating cells is increased
• increased number of recirculating mature B cells
• in the bone marrow and lymph nodes
• relative number of circulating cells is increased
• 80% fewer leukocytes than in controls
• decreased number of circulating B cells
• decrease in pro/pre-B cells
• in the blood and spleen
• absolute numbers of all T cell types is reduced
• 45% lower spleen cellularity
• 20% lower spleen weight
• marginal zone B cell numbers are maintained but all other types are reduced
• NK cells exhibit increased migration to CXCL12 gradients compared with wild-type cells

endocrine/exocrine glands
• 30% reduction in thymus cellularity

Mouse Models of Human Disease
OMIM ID Ref(s)
Whim Syndrome; WHIMS 193670 J:186735


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory