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Phenotypes Associated with This Genotype
Genotype
MGI:5301335
Allelic
Composition
B9d1tm1a(EUCOMM)Wtsi/B9d1tm1a(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6N * CD-1
Cell Lines EPD0060_2_H09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d1tm1a(EUCOMM)Wtsi mutation (1 available); any B9d1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• in some mice

mortality/aging
• mice die between E17.5 and P1

renal/urinary system
• at E18.5, kidneys exhibit dilation and cystic pathology in multiple nephrons segments unlike wild-type mice
• at E18.5
• at E18.5
• at E18.5

nervous system
• in 3 of 49 mice at E11.5
• in some mice at E10.5

liver/biliary system
• ductal plates persisted as peripheral rings at P1
• however, bile ducts develop cilia
• at P1, hyperplastic portal mesenchyme separate enlarged bile ducts from portal veins unlike in wild-type mice

cardiovascular system
• in some mice
• in 20 of 45 mice
• in some mice at E13.5

craniofacial
• at E10.5, mice display midline facial defects
• in 9 of 19 mice at E13.5

vision/eye
• in 32 of 37 mice

limbs/digits/tail
• with either one or two extra digits at E13.5
• more prevalent in the hind limbs than fore limbs

embryo
• the few nodal cilia that form are short with swollen tips

endocrine/exocrine glands
• ductal plates persisted as peripheral rings at P1
• however, bile ducts develop cilia

digestive/alimentary system
• in 9 of 19 mice at E13.5

cellular
• the few nodal cilia that form are short with swollen tips

growth/size/body
• at E10.5, mice display midline facial defects
• in 9 of 19 mice at E13.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Meckel syndrome DOID:0050778 J:178421


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory