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Phenotypes Associated with This Genotype
Genotype
MGI:5297860
Allelic
Composition
Ay/a
Apoetm1Unc/Apoetm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (350 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (64 available)
Ay mutation (10 available); any a mutation (350 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants develop larger atherosclerotic plaques than a/a Apoetm1Unc/Apoetm1Unc mice (J:177084)
• plaques contain a higher proportion of macrophage infiltration (J:177084)
• mutants develop larger atherosclerotic plaques than a/a Apoetm1Unc/Apoetm1Unc mice (J:177084)
• plaques contain a higher proportion of macrophage infiltration (J:177084)

growth/size/body
• mutants exhibit increased weight gain, despite similar food intake as controls (J:177084)
• mutants exhibit increased weight gain, despite similar food intake as controls (J:177084)

hematopoietic system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads (J:177084)
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads (J:177084)

homeostasis/metabolism

immune system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads (J:177084)
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads (J:177084)
• increase in systemic inflammation (J:177084)
• increase in systemic inflammation (J:177084)

renal/urinary system
• mutants develop features of diabetic nephropathy (J:177084)
• mutants develop features of diabetic nephropathy (J:177084)
• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli (J:177084)
• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli (J:177084)
• 20-30% of mutants exhibit nodular sclerosis in the kidney (J:177084)
• 20-30% of mutants exhibit nodular sclerosis in the kidney (J:177084)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory