Mouse Genome Informatics
cx
    Ay/a
Apoetm1Unc/Apoetm1Unc

involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• mutants develop larger atherosclerotic plaques than a/a Apoetm1Unc/Apoetm1Unc mice
• plaques contain a higher proportion of macrophage infiltration

growth/size/body
• mutants exhibit increased weight gain, despite similar food intake as controls

hematopoietic system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

homeostasis/metabolism

immune system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads
• increase in systemic inflammation

renal/urinary system
• mutants develop features of diabetic nephropathy
• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli
• 20-30% of mutants exhibit nodular sclerosis in the kidney