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Phenotypes Associated with This Genotype
Genotype
MGI:5297821
Allelic
Composition
Dnmt3atm1Jae/Dnmt3atm1Jae
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Tg(Ins2-cre)23Herr/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm1Jae mutation (1 available); any Dnmt3a mutation (138 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (935 available)
Nkx2-2tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Ins2-cre)23Herr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice exhibit beta to alpha cell transdifferentiation

cellular
• mice exhibit beta to alpha cell transdifferentiation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory