Mouse Genome Informatics
ht
    Frem1bat/Frem1+
C57BL/6J-Frem1bat
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
• 42% of heterozygotes exhibit variable sutural abnormalities, including complete fusion, sutural asymmetry and advanced endocranial suture fusion
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia

skeleton
• 42% of heterozygotes exhibit variable sutural abnormalities, including complete fusion, sutural asymmetry and advanced endocranial suture fusion
• mutants exhibit anterofrontal cranial deformation similar to metopic craniosynostosis and trigonocephaly, although less severe than seen in homozygotes

growth/size/body
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia
• 2 of 21 mutants exhibit varying degrees of midfacial asymmetry and/or midface hypoplasia

Mouse Models of Human Disease
OMIM IDRef(s)
Chromosome 9p Deletion Syndrome 158170 J:177282