Phenotypes for Reg3g MGI:5295377 MGI Mouse

digestive/alimentary phenotype ( J:177506 )

N	• mice exhibit normal intestinal morphology

abnormal feces composition ( J:177506 )

• increased fecal IgA and albumin

• however, antibody treatment restores normal fecal IgA levels

abnormal gut flora balance ( J:177506 )

• mice exhibit a higher mucosal bacterial loads (gram-positive Firmicutes phylum [Lactobacillus, Eubacterium rectale, and segmented filamentous bacteria (SFB) groups]) compared with wild-type mice

• however, luminal bacterial loads are normal

abnormal intestine physiology ( J:177506 )

• intestinal permeability (measured by fecal albumin) is increased compared to in wild-type mice

immune system phenotype ( J:177506 )

N	• mice exhibit normal numbers of Th17 and regulatory T cells

increased T-helper 1 cell number ( J:177506 )

• in the intestinal lamina propria

• however, antibody treatment restores normal IFN-gamma-producing Th1 cell numbers

increased IgA level ( J:177506 )

• mice exhibit increased IgA+ cells in the small intestinal lamina propria and increased fecal IgA compared with wild-type mice

• however, antibody treatment restores normal IgA cell numbers