Phenotypes Associated with This Genotype

Genotype
MGI:5295254

• Allelic Composition: Nfatc1^tm1Rao/Nfatc1^tm1Rao; Tg(Fcer2a-cre)5Mbu/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell physiology ( J:177319 )

• stimulated B cells exhibit reduced ability to induced T cell proliferation

decreased B cell proliferation ( J:177319 )

• alpha-IgM-mediated

• however, LPS-stimulated B cell proliferation is normal

abnormal class switch recombination ( J:177319 )

• to IgG3 induced by T cell-independent type II antigens

decreased IgG2a level ( J:177319 )

• after immunization with NP-KLH

decreased IgG3 level ( J:177319 )

• 10-fold after immunization with NP-Ficoll

decreased IgM level ( J:177319 )

• after immunization with NP-Ficoll

increased IgM level ( J:177319 )

• in unstimulated B cells

increased interleukin-10 secretion ( J:177319 )

• from LPS-stimulated B cells

decreased interleukin-2 secretion ( J:177319 )

• from stimulated B cells

hematopoietic system

abnormal B cell physiology ( J:177319 )

• stimulated B cells exhibit reduced ability to induced T cell proliferation

decreased B cell proliferation ( J:177319 )

• alpha-IgM-mediated

• however, LPS-stimulated B cell proliferation is normal

abnormal class switch recombination ( J:177319 )

• to IgG3 induced by T cell-independent type II antigens

decreased IgG2a level ( J:177319 )

• after immunization with NP-KLH

decreased IgG3 level ( J:177319 )

• 10-fold after immunization with NP-Ficoll

decreased IgM level ( J:177319 )

• after immunization with NP-Ficoll

increased IgM level ( J:177319 )

• in unstimulated B cells

cellular

decreased B cell proliferation ( J:177319 )

• alpha-IgM-mediated

• however, LPS-stimulated B cell proliferation is normal