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Phenotypes Associated with This Genotype
Genotype
MGI:5295221
Allelic
Composition
L1camtm1.1Pfm/L1camtm1.1Pfm
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1camtm1.1Pfm mutation (0 available); any L1cam mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• unlike null mice, the size and morphology of the superior colliculus, neocortex, hippocampus, thalamus, and cerebellum are normal
• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus
• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning
• retinal axons exhibit misdirected interstitial branching during development
• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus
• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning
• retinal axons exhibit misdirected interstitial branching during development

vision/eye
• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus
• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning
• retinal axons exhibit misdirected interstitial branching during development

cellular
• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus
• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning
• retinal axons exhibit misdirected interstitial branching during development


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory